Endocrine Abstracts

Introduction: Due to the growing prevalence of obesity, more women are overweight in early pregnancy, leading to adverse neonatal and obstetric outcomes.Objective: To evaluate the influence of maternal prepregnancy body mass index (BMI) on blood glucose levels at diagnosis of gestational diabetes (GD), obstetric and neonatal outcomes.Methods: Retrospective observational study including women with GD and singleton pregnancy, with fo...

Introduction: Different pharmacological therapies for obesity have become available in the last years. It is important to know their effectiveness in real-world practice and their acceptance among patients.Objectives: To analyze the anthropometric changes, daily dosis, side effects and treatment withdrawal in patients treated with Liraglutide or Naltrexone/Bupropion in clinical practice.Material and methods: Retrospective descripti...

Introduction: The American Diabetes Association guideline states that the long-term use of metformin may be associated with biochemical vitamin B12 (B12) deficiency and periodic measurement should be considered, although isolated serum B12 measurement has low sensitivity and specificity. Homocysteine (Hcy) and methylmalonic acid (MMA) are more sensitive biomarkers, the latter being more specific.Objectives: To estimate B12 deficiency in type 2 diabetics ...

Introduction: Hypophysary aneurysms are rare, they account for 1% to 2% of all intracranial aneurysms (1) and can be mistaken for pituitary adenomas, since they can have similar symptoms and even radiological signs especially if it’s an aneurysm completely thrombosed as angiography will show only avascular mass (2).Clinical case: A 84 year old female with past medical history of hypertension, dyslipidemia and depressive disorder, presents to emergen...

Introduction and Objectives: The incidence of thyroid cancer has increased worldwide. This increase has been attributed to more diagnosed papillary thyroid microcarcinomas. The purpose of this study was to analyse the growing trend of first appointments in our Thyroid Cancer Unit, namely patients with papillary microcarcinomas.Methods: We performed a retrospective study based on the patients diagnosed with thyroid cancer between 1960 and 2016. We divided...

Introduction: Congenital hyperinsulinism (CHI) is a heterogenous disease caused by insulin secretion regulatory defects, being ABCC8/KCNJ11 the most commonly affected genes. It can present as focal or diffuse pancreatic disease, which is mainly determined by the genotype. Diazoxide is the first-line medication in diffuse cases, however many do not respond satisfactory. Second-line options include somatostatin analogues and surgery, which is curative in case of focal CHI.<p...

Introduction: Esthesioneuroblastoma is an uncommon malignant neoplasm with an average 5-year survival rate of about 45%. Ectopic ACTH syndrome due to esthesioneuroblastoma is extremely rare and there have been very few cases reported.Case report: A 54-year-old woman was admitted to our hospital with symptoms of leg edema and general fatigue of one month’s duration. Physical examination showed moon facies and edema on her lower extremities bilaterall...

Germinal mutations of the oncogene RET originate the development of medullary thyroid carcinoma (MTC) in carriers with phenotypic expression depending on the mutated codon and other unknown factors. Simultaneous detection of differentiated thyroid carcinomas is considered a casual phenomenon (collision tumours). We communicate two brothers with double heterozygous mutation of maternal inheritance at codon 611 of RET, TGC to TTT, changing to encode phenylalanine (C611F), with a...

Medullary thyroid carcinoma (MTC) is a rare tumor of C cell origin, that may be sporadic or familial. Diagnosis is often delayed and its course variable.Objectives: Evaluation of clinical characteristics and outcome of patients diagnosed with MTC.Methods: Retrospective analysis of clinical records of patients with MTC between 2005 and 2016. We considered undetectable serum calcitonin as criteria of cure.Resul...

Case report: 66 year old male with a neck growing mass performed an ultrasonography and fine-needle aspiration biopsy which was suspicious for papillary carcinoma. The patient was submitted to total thyroidectomy and central and left lateral compartments lymph node dissection. The histological report showed a follicular carcinoma of 9 cm, with multiple lymphovascular invasions and skeletal muscle invasion. There was a focally positive surgical margin and resected lymph nodes h...